I really enjoy your balanced, in-depth look at issues. I appreciate you taking us along as you investigate and research these important topics. I have learned you really have to be careful and question when someone is peddling "answers" to problems they write about.
Excellent article and insight. I work with cancer patients and have had similar concerns. Does it make sense to use more TMG 1 gram/day in high homocysteine and dietary folic acid in leafy greens in metastatic cancer rather than any methylfolate? B6 in moderate doses with adequate Zinc/B12 would pose less of a risk of proliferating cancer?
It's a balance of growth vs cellular health, whether using forms of choline or folate in leafy greens. It likely also depends on the type of cancer and whether antifolate medications are being used.
Folic acid is a synthetic form of folate that is added to fortified foods and vitamins. Both folic acid and folate have to undergo changes after they are absorbed to be able to be used in the cells.
If you want to get deep in the weeds on this topic, here are a few article on how folate is absorbed, transported, and used in the cell:
I really enjoy your balanced, in-depth look at issues. I appreciate you taking us along as you investigate and research these important topics. I have learned you really have to be careful and question when someone is peddling "answers" to problems they write about.
Excellent article and insight. I work with cancer patients and have had similar concerns. Does it make sense to use more TMG 1 gram/day in high homocysteine and dietary folic acid in leafy greens in metastatic cancer rather than any methylfolate? B6 in moderate doses with adequate Zinc/B12 would pose less of a risk of proliferating cancer?
It's a balance of growth vs cellular health, whether using forms of choline or folate in leafy greens. It likely also depends on the type of cancer and whether antifolate medications are being used.
With high homocysteine, there are studies showing riboflavin and B6 often help. https://www.geneticlifehacks.com/understanding-homocysteine-levels/
Are folic acid and folate interchangeable?
Folic acid is a synthetic form of folate that is added to fortified foods and vitamins. Both folic acid and folate have to undergo changes after they are absorbed to be able to be used in the cells.
If you want to get deep in the weeds on this topic, here are a few article on how folate is absorbed, transported, and used in the cell:
https://www.geneticlifehacks.com/folr1-and-folr2-transporting-folate-and-folic-acid-into-cells/
https://www.geneticlifehacks.com/folic-acid-supplementation-and-your-genes/
https://www.geneticlifehacks.com/mthfr/